No. The ISA wrapper is invisible to US law: interest, dividends and gains inside an ISA are taxable on your US return in the year earned. A stocks-and-shares ISA holding UK funds is usually worse than taxable, because UK-domiciled funds are PFICs, bringing Form 8621 and the punitive section 1291 regime.
ISAs count toward FBAR and Form 8938 thresholds. A cash ISA is a mild annual tax leak for a US person; a fund ISA is a reporting problem worth restructuring.